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Types of lymphoma

  

Diagnosis & Pathology | Grade | Lymphatic System | What's Lymphoma?Lymphoma simplified | Prognosis | Risk Factors | Stage | Symptoms | Transformation | Types of Lymphoma

Types of Lymphoma

Last Update: 08/14/2008

Lymphomas are a diverse group of related cancers that affect lymphocytes - a type of white blood cell. 

Aggressive & Indolent types | Extranodal  (Cutaneous) areas of presentation 

Also see Detailed Classifications & Resources

 

Acute lymphocytic leukemia (ALL)

Anaplastic Large Cell

AIDS / HIV - related lymphoma

Burkitt's
aggressive, effects children primarily

Central Nervous System (CNS)
 aggressive, rare

Childhood

Chronic Lymphocytic Lymphoma (CLL/SLL)

Diffuse Large B-Cell  
most common aggressive;
b-cell type

Extranodal Cutaneous | Gastric | Hepatic | Conjunctival / Ocular / Eyelid / Orbital | Osteo (bone) | Oral | Testis

EBV-Related

Follicular most common indolent (grade 1&2), b-cell type Grade 3 Follicular intermediate grade, large b-cell

Hairy Cell Leukemia

Hodgkin's 
less common than NHL, most common in young adults;  good prognosis

Large Cell

Lymphomatoid papulosis

Lymphoid granulomatosis (LYG)

Mantle Cell  (MCL)
less common, b-cell type

Marginal Zone type: MALT | BALT less common indolent, b-cell type; good prognosis

Post transplant 
lymphoproliferative disorder
 PTLD

Primary Mediastinal  B-Cell
 rare, clinically favorable subgroup of Diffuse Large B Cell Lymphoma related to Hodgkin Lymphoma

Splenic, primary

Splenic with Villous Lymphocytes

Testicular

T-cell types 
less common than b-cell types
Cutaneous | Mycosis Fungoides
NK Cell | Peripheral 

Waldenstrom's
Macroglobulinemia

Waldeyer's Ring

Other Lymphomas 


Acute lymphocytic leukemia (ALL)

PubMed abstracts: Review | TherapyDiagnosis

acute lymphocytic 
leukemia (ALL)

Also see Childhood Lymphoma

B-cell stage: stem cell
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"ALL is the most common cancer occurring in children, representing 23% of cancer diagnoses among children younger than 15 years of age and occurring at an annual rate of approximately 31 per million. There are approximately 2,400 children and adolescents younger than 20 years of age diagnosed with ALL each year in the United States.

There is a sharp peak in ALL incidence among children ages 2 to 3 years (> 80 per million per year), with rates decreasing to 20 per million for ages 8 to 10 years." - NCI 2002 [1]

  1. Childhood Acute Lymphoblastic Leukemia- NCI  - for Health Professionals
    Important: review links at the bottom of the NCI site for studies related to treatment.
  2. About Adult Acute Lymphoblastic Leukemia  Cancer.gov 
AIDS / HIV - Related Lymphoma
AIDS / HIV - Related Lymphoma
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We have moved this topic to a new page
Burkitt's
Burkitt's
Also see:
Childhood Burkitt's Lymphoma
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We have moved this topic to a new page. 

See Burkitt's lymphomas

Lymphomatoid papulosis

TOPIC SEARCH: PubMed

Lymphomatoid 
papulosis
(LyP)
has been described as a "self-healing" lymphoma
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"Lymphomatoid papulosis (LyP; Macaulay disease) is a chronic lymphoproliferative (lymphocytes dividing and expanding rapidly) disease of the skin characterized by recurrent crops of pruritic (itching) papules that may ulcerate. The papules heal spontaneously over a period of 1-2 months, usually leaving slightly depressed oval scars."  e-medicine

About   e-medicine | dermnetnz.org | Lymphomainfo.net | skinsite.com
 dermvic.org 
Images  dermnetnz.org | hmds.org 
Clonal T-cell populations in lymphomatoid papulosis. Evidence of a lymphoproliferative origin for a clinically benign disease  NEJM
Support rochester.edu
Lymphoid granulomatosis (LYG)

TOPIC SEARCH: PubMed

Lymphoid granulomatosi
 
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"Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin." [3] which is frequently associated with Epstein-Barr virus infection. [4]

"The pathogenesis of LYG is unknown; however, recent studies have provided overwhelming evidence that LYG is a distinctive type of malignant lymphoma associated with immunosuppression."  e-medicine

  1. About   e-medicine 
  2. Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy. Eur J Haematol. 2005 Mar;74(3):263-6. PMID: 15693798 | Related articles
  3. Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab.
    Eur Respir J. 2006 Mar;27(3):644-6. PMID: 16507866
  4. [Efficacy of rituximab in lymphomatoid granulomatosis] Rev Mal Respir. 2004 Dec;21(6 Pt 1):1157-61. French. PMID: 15767962 | Related articles
  5. Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis.
    Am J Surg Pathol. 1994 Aug;18(8):753-64. PMID: 8037289
Splenic Lymphoma with Villous Lymphocytes

TOPIC SEARCH: ASCO | Medscape | PubMed

Splenic Lymphoma with Villous Lymphocytes
B-cell stage: mature, before antigen exposure
Associated with
hepatitis C virus
Often misdiagnosed as CLL
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"Splenic lymphoma with villous lymphocytes (SLVL) is a recently recognized entity among chronic B lymphoproliferative disorders. It has a distinct clinical, morphological and immunophenotypic pattern and was previously described under a variety of designations. SLVL can be misdiagnosed as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL), or hairy cell leukemia (HCL)."  kfshrc.edu.sa

Also see: Marginal Zone - Splenic

About  infobiogen.fr  
Splenic lymphoma in presence of HCV may respond to interferon alpha  Reuters Health Jul_10_02 (link repaired May 2004) And see mediscover.net 
Dramatic efficacy of fludarabine in the treatment of an aggressive case of splenic lymphoma with villous lymphocytes. Eur J Haematol. 2002 Aug;69(2):112-4.
PMID: 12366716  PubMed 
Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Engl J Med. 2002 Jul 11;347(2):89-94. PMID: 12110736  PubMed
Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood. 2001 Nov 1;98(9):2837-44. abstract | related abstracts
Waldeyer's ring lymphomas

TOPIC SEARCH: ASCO | Medscape | PubMed

Waldeyer's ring lymphomas
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"It is debated whether non-Hodgkin's lymphomas originating in Waldeyer's ring (WR NHL) behave as NHL originating in lymph nodes or share common features with extranodal lymphomas originating in mucosa associated lymphatic tissue (MALT). 

We analyzed data from a population based NHL registry on patterns of dissemination at diagnosis, response to treatment, patterns of failure and survival of 77 primary Waldeyer's ring Non-Hodgkin's lymphomas (WR NHL) patents. Data of completely staged patients with diffuse large cell lymphomas (DLCL) originating in WR (n=44) were compared with those of patients retrieved from the same registry with DLCL originating in lymph nodes or stomach (the latter as prototype of a lymphoma originating in MALT). 

Primary WR NHL had favorable risk scores according to the International Prognostic Index (IPI), and responded well to therapy: a complete response (CR) rate of 74% was observed. 

Disease free survival (DFS) and overall survival (OS) were poor, however (47% and 31% at 10 years, respectively). The comparison of DLCL originating in WR, lymph nodes and stomach revealed that WR and gastric NHL patients shared a restricted pattern of dissemination at diagnosis, in contrast to patients with DLCL originating in lymph nodes." 1

  1. Waldeyer's ring lymphomas: a clinical study from the Comprehensive Cancer Center West population based NHL registry. Leuk Lymphoma. 2001 Sep-Oct;42(5):1005-13.
    PMID: 11697617
  2. Waldeyer's ring lymphomas: the prognostic factors and the treatment outcome Year: 2002 Abstract No: 1138
Post Transplant Lymphoproliferative Disorder (PTLD) 

TOPIC SEARCH: ASCO | ClinicalTrials.gov | Medscape | PubMed

 Post Transplant Lymphoproliferative Disorder (PTLD) 
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"Post-transplant lymphoproliferative disorders (PTLD) are a diverse group of abnormal lymphoid [a type of white blood cell] growths that include both hyperplasias [An abnormal increase in the number of cells in an organ or tissue]

They have been divided into several general pathologic categories that have prognostic [outcome] significance. These include early or hyperplastic PTLD, polymorphic PTLD, and lymphomatous or monomorphic PTLD. 

The majority of PTLDs are of B-cell origin and contain Epstein-Barr virus (EBV). However, PTLDs of T- or NK-cell origin have been described, and late-arising EBV-negative lymphoid tumors are becoming more frequently reported in this population." 3

  1. Discovery of mechanism that may explain post-transplant lymphoproliferative disorder  newsmedicinenet
  2. Post-transplant lymphoproliferative disorder is the most common malignancy, with the exception of skin cancer, after solid organ transplantation in adults. The incidence varies according to the transplanted organ and is often associated with Epstein-Barr virus. Prognosis is variable, due in part to the heterogeneity of the disease, which ranges from reactive plasmacytic hyperplasia to aggressive monoclonal disease.  oncologist
  3. The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach. Transpl Infect Dis. 2001 Jun;3(2):88-96. Review. 
    PMID: 11395974
Other Lymphomas / pseudotumors
 Other lymphomas
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Thyroid Lymphoma  emedicine
Inflammatory pseudotumor in lymph nodes  pathologyoutlines.com
 
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For all medical concerns,  you should always consult your doctor. 
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