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About NHL > Types of Lymphoma > T-cell > delta/gamma

Last update: 11/23/2012

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Delta Gamma is a provisional subtype of t-cell lymphomas.

"'Expression of TCR gamma delta on tumor cells was found in 

bullet five (33%) of 15 patients with precursor T-cell lymphoblastic leukemia/lymphoma, 
bullet one (25%) of four with T-cell granular lymphocytic leukemia 
bullet and five (26%) of 19 with peripheral T-cell lymphoma (PTCL), 
bullet whereas no expression was found in 11 patients with adult T-cell leukemia-lymphoma." 
Source: Gamma delta T-cell neoplasms: a clinicopathological study of 11 cases. Ann Oncol. 2002 Nov;13(11):1792-8. Review. PMID: 12419753 

 

Patient Story posted to WebMagic (with no  identifying information) with links to other stories:

"It has been seven months since my diagnosis and 4 months since the transplant. I am fortunate to be making an incredibly smooth recovery after my transplant. My counts are great, almost completely normal CBC and chemistry. My stamina and energy is back and I can go hiking again with my wife and my dogs. I have not been re-hospitalized since the day I checked out. My magnesium has stabilized and I no longer need IV infusions. I just had my hickman catheter removed this week and it feels so good to not have a big plastic squid hanging out of my chest! And the best news of all is that I just got the results of the 3 month bone marrow and my cells are 100% my sisters, with no evidence of cancer!

I did get some mild GVHD in the form of a skin rash and some GI upset at around the 2 month mark. Steroid cream and budesonide treated both respectively and I did not need to go on pred. I was kind of OK with this. Supposedly people who have mild graft vs host have a lower chance of tumor recurrence.

I still have a long way to go before I feel like I am out of the woods, but I am back to feeling relatively healthy for the first time in a long time.

Also, for those of you that come across this thread looking for info on this rare disease, I would like to point you to another thread on the cancer survivors network that has a bunch of great information. I recently posted my complete treatment plan over there.

http://csn.cancer.org/node/136135

 

Hepatosplenic T-cell lymphoma (HSTCL)

"HSTCL is a rare aggressive type of extranodal lymphoma characterized by hepatosplenomegaly, bone marrow involvement, and peripheral blood cytopenias. HSTCL exhibits a distinctive pattern of infiltration; tumor cells
preferentially infiltrate the sinusoids of the splenic red pulp, liver, and bone marrow.

The tumor cells have a nonactivated cytotoxic T-cell immunophenotype and frequently carry a recurrent cytogenetic abnormality, isochromosome 7q. Most cases express the γδ T-cell receptor, but cases can have an αβ phenotype and are considered to be a variant of the disease. Although HSTCL is the prototype peripheral T-cell lymphoma expressing the γδ T-cell receptor, non-HSTCL proliferations of γδ T cells can involve other extranodal sites, mainly skin and mucosa. These γδ T-cell lymphomas display marked heterogeneity in clinical and histologic features. In contrast with HSTCL, non-HSTCL γδ T-cell lymphomas frequently have an activated cytotoxic phenotype and most likely are not a single disease entity. 

Source: Hepatosplenic and Other gammadelta T-Cell Lymphomas

bullet
AJCP, 2005: Hepatosplenic and Other gammadelta T-Cell Lymphomas
bullet
Pediatr Rep. 2010 - case report
A seventeen-year-old female with hepatosplenic T-cell lymphoma associated with parvoviral infection
bullet Also, for those of you that come across this thread looking for info on this rare disease, I would like to point you to another thread on the cancer survivors network that has a bunch of great information. I recently posted my complete treatment plan over there.

http://csn.cancer.org/node/136135


Resources

bullet
About Delta Gamma CTCL of skin (cutaneous)  - Doctorsdoctor
bullet
Refractory disease - PAL
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PubMed Queries on This Subtype of Lymphoma

bullet
 Diagnosis | Review | Therapies | Prognosis | Other Related abstracts
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Clinical Trials

bullet
ClinicalTrials.gov studies for T-cell lymphomas: Untreated | Recurrent  
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Research News

bullet
Gamma delta T-cell neoplasms: a clinicopathological study of 11 cases. Ann Oncol. 2002 Nov;13(11):1792-8. Review. PMID: 12419753 
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