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Free Kappa and Lambda Light
Chains Plus Ratio
B-cell
carries either kappa- or lambda-light chains on its surface (a
distinctive marker).
Normal, polyclonal B-cells are a
mixture of kappa-B-cells and lambda-B-cells (one marker or the
other)
When malignant B-cell clone proliferates it will lead to b-cell
population consisting
of either only kappa- or only lambda-B-cells. (one marker,
and not the other, suggests malignancy)
Adapted from
med4you.
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