is a bacteria responsible for one of the most common
infections found in humans worldwide. It is associated with MALT
lymphoma. Importantly, when associated with MALT, eradication of the
infection can cause the lymphoma to resolve.
"Helicobacter pylori has been claimed to be an
important aetiological (causative) factor which raises the risk of
mucosa-associated tissue lymphoid (MALT) lymphoma. However, some
studies on gastric MALT lymphoma revealed a low rate of H. pylori
infection suggesting that not all gastric lymphomas are related to H.
pylori infection." 6
- Serologic assay of anti-HP immunoglobulin G
- Urea breath test
- Antigens in feces
- Biopsies from endoscopy, followed by:
- Histologic examination of gastric tissue
- Rapid urease testing
- Culture of organisms
- Cytological analysis
- PCR testing to identify H-pylori DNA 7
false-negative test results: Avoid antibiotics, bismuth compounds, or PPIs
2 weeks prior to tests.3
"Serologic testing and endoscopy are clearly the most inexpensive and expensive
methods, respectively, for diagnosing infection in an untreated patient.
Selection of the appropriate test for a patient is dependent upon the clinical situation.
With all diagnostic tests except serologic assays, a particularly important consideration is the potential
for false-negative results in patients who have taken antibiotics, bismuth compounds, or
proton pump inhibitor (PPI) acid suppression in the
past 1 to 2 weeks." 3
Randomized trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspeps -
Conclusion: In this patient group, non-invasive testing (Breath
Test) for H pylori is as effective and safe as endoscopy and less uncomfortable and distressing for the patient. Non-invasive H pylori testing should be the preferred mode of investigation.
Note: But endoscopy might be most appropriate when also
diagnosing for MALT.
H.Pylori Home Test Kit-(commercial) - equiptrip.com
Improving H-Pylori Therapy - pec.ha.osd.pdf
(Includes information about how to avoid false-negatives.)
Which test to use to detect Helicobacter pylori infection in
patients with low-grade gastric mucosa-associated lymphoid tissue
lymphoma? Am J Gastroenterol. 2003 Feb;98(2):291-5.
Because gastric MALT lymphoma is a rare disease, few studies comparing the accuracy of diagnostic tests in this group of patients have been carried out, and only a limited number of tests (essentially histological) were performed.
The aim of our study was to compare the results of four different diagnostic methods used to detect H. pylori (histology, culture, polymerase chain reaction, and serology) in a prospective multicenter study.
A patient was considered to be H. pylori positive if culture or histology was positive.
During the period 1995-2000, a total of 90 patients with low-grade gastric MALT lymphoma were enrolled.
Results for the four tests were available for 56 patients (62.2%). Among these
the four tests were concordant in 35 cases (62.5%),
i.e., were positive in 19 cases (33.9%) and negative in 16 patients (17.8%).
Histology (39/40 positive, 97.5%)
and serology (38/40 positive, 95.0%) were the most sensitive
Polymerase chain reaction (PCR) and culture were positive in 52.5% and 50%, respectively.
The cagA gene was detected in 47.4% of the strains.
The role of Helicobacter pylori in primary gastric MALT
Histopathology. 1999 Feb;34(2):118-23. PMID: