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Tests > Other Tests

Last Update: 03/06/2011

 
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DiSC Assay

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Doppler

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Endoscopy

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Epstein-Barr

DiSC assay
(optional)
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DiSC assay

Differential Staining Cytotoxicity (DiSC) may be useful to determine which treatment agents are less likely to work on your particular tumor cells.

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Doppler, Venous
(not common)
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Doppler, Venous

The Venous Doppler test checks the blood flow in the veins which carries the blood back to the heart. This test might be called for to determine if enlarged lymph nodes are preventing the flow of blood. "Doppler ultrasonography uses audio means to hear the "swishing" noise of the blood flow." [1]
 

  1. About  Medline Plus 
Endoscopy
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Endoscopy

Look inside the body with an endoscope -- a long tube with a camera and a light inside it. This procedure may be used to investigate the esophagus, stomach, or colon.

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Epstein-Barr

"Diseases caused by the virus are particularly common among people with reduced immunity
For example, the virus is associated with ‘post-transplant lymphoproliferative disease’, a tumour often found in organ transplant 
patients." [3]

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QUESTION: What is Epstein-Barr virus? 

"It's a member of the herpes virus family; one of the most common human viruses. 

The virus occurs worldwide, and most people become infected with EBV sometime during their lives. 

In the United States, as many as 95% of adults between 35 and 40 years of age have been infected. Infants become susceptible to EBV as soon as maternal antibody protection (present at birth) disappears. 

Many children become infected with EBV, and these infections usually cause no symptoms or are indistinguishable from the other mild, brief illnesses of childhood. 

When the first infection with EBV occurs during adolescence or young adulthood, it causes infectious mononucleosis 35% to 50% of the time.

Symptoms of infectious mononucleosis are fever, sore throat, and swollen lymph glands. Sometimes, a swollen spleen or liver involvement may develop.  ...  

Although the symptoms of infectious mononucleosis usually resolve in 1 or 2 months, EBV remains dormant or latent in a few cells in the throat and blood for the rest of the person's life. Periodically, the virus can reactivate and is commonly found in the saliva of infected persons. This reactivation usually occurs without symptoms of illness." 

Adapted from:  www.cdc.gov 

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QUESTION:  What type of doctor should I consult for swollen glands 
when testing positive of EBV?

Your primary care doctor might refer you to a hematologist - a physicians that study, diagnose, and treat blood diseases.
www.findahematologist.org

To locate board certified hematologists, see Located Doctors

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QUESTION:  What is meant by Titer of EBV?

Titers is a measurement of the concentration of a substance in a solution. It refers to the amount of antibodies made by the immune system to EBV found in a patient's blood. 

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QUESTION:  What is the connection between EBV and Lymphoma?

EBV is strongly associated with a rare type of lymphoma, called Burkitt's lymphoma.  It's also associated with Hodgkins lymphoma.  

It's not known if EBV is the cause of these illnesses, or simply an associated marker. "It is proposed (not proven) that cellular immune deficiencies, involving decreased cytotoxic/suppressor T cell and/or natural killer cell function, cause these chronic illnesses, and that elevated EBV antibodies reflect the underlying cellular immune deficiencies" ourworld.compuserve.com

"The Epstein-Barr virus (EBV) has been implicated strongly in the African form, while the relationship is less clear in the sporadic form. EBV is associated with about 20% of sporadic cases. Rare adult cases are associated with immunodeficiency, particularly AIDS. 

The lymphocytes have receptors for EBV and are its specific target. In the African form, the hosts are believed to be unable to mount an appropriate immune response to primary EBV infection, possibly because of coexistent malaria or another infection that is immunosuppressive. Months to years later, excessive B cell proliferation occurs."

emedicine.com/med/topic256.htm 

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Resources
  1. About EBV  CDC 

    Learn how past exposure, reactivation,
    and chronic EBV can be identified by testing.  
  2. Tutorial on EBV  MedlinePlus (Req Flash plug in)
  3. Kissing the Epstein-Barr virus goodbye? science.org
  4. Lymph node disorders emedicine.com
  5. EBV serology http://ourworld.compuserve.com 
 
Disclaimer:  The information on Lymphomation.org is not intended to be a substitute for 
professional medical advice or to replace your relationship with a physician.
For all medical concerns,  you should always consult your doctor. 
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