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Types of Lymphoma > Large Cell Lymphomas

Last update: 05/30/2013

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Large Cell Lymphomas 

Generally these are fast growing cancer of b- or t-cells (lymphocytes) - a type of immune cell.   Large Cell Lymphomas (LCL) are one of the most common types of aggressive lymphoma, comprising about 31% of lymphomas.  These lymphomas appear in both children and adults.

What is lymphoma? It is a condition where abnormal blood cells accumulate - typically in the in the lymphatic system, including the spleen or bone marrow.

See Lymphoma simplified for more detail.

The clinical and pathological features of non-Hodgkin's lymphomas are diverse. For example, there is large cell lymphoma and also intermediate grade or high grade lymphoma.   Increasingly, the diagnosis of large cell lymphoma is more refined - beyond the size of the cells - based instead on the type of lymphocyte that is defective and molecular characteristics.

Diffuse Large B Cell Lymphoma accounts for for about 30% of all non Hodgkin lymphomas. It may first show itself as a extra-nodal mass -- outside the lymphatic system --  or as a rapidly growing nodal mass (enlarging lymph node).  
 

See Diffuse Cell Lymphoma page.

The characteristics of the lymphoma at diagnosis as determined by the pathology report, and it's actual clinical behavior, and other factors determine the type of treatment and the timing of treatment you and your doctor will consider. 

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Follicular grade 3 lymphoma - related abstracts
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See Factors that determine treatment timing and approach
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Your age and treatment priorities

Types of large cell lymphomas

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Lymphoma Series: Variants of Large-Cell Lymphoma  theoncologist.alphamedpress.org  | Full PDF
 
Introduction to a Special Series of Unique Entities Within the Spectrum of Large-Cell Lymphoma, George P. Canellos, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA 
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Anaplastic Large Cell Lymphoma
(5% of all non Hodgkin Lymphomas)
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Diffuse Large Cell & Diffuse Mixed Cell
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Large-Cell, Immunoblastic (high grade) *
PubMed abstracts: ReviewTherapyDiagnosis
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Large B-cell lymphoma  PubMed
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Lymphoblastic (high grade) *
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Large-Cell, Follicular * Also see Follicular
PubMed abstracts: Review | TherapyDiagnosis
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Large-Cell, Ki-1 *
PubMed abstracts: ReviewTherapyDiagnosis
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T Cell Rich Large B Cell Lymphoma 
(a rare subtype of large B cell lymphoma)
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PubMed articles  All related articles | PubMed
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T-Cell/Histiocyte–Rich Large B-Cell Lymphoma: A Distinct Clinicopathologic Entity By R. Achten   jco.org 
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T-Cell/Histiocyte-Rich Large B-Cell Lymphomas and Classical Diffuse Large B-Cell Lymphomas Have Similar Outcome After Chemotherapy: A Matched-Control Analysis  R. Bouabdallah,et al  jco.org

OTHER TYPES

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Intravascular B-cell lymphomas (rare)
Report of two cases with different clinical presentation but rapid central nervous system involvement. Leuk Lymphoma. 2003 Aug;44(8):1353-9. PMID: 12952229  Abstracts
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Primary Mediastinal B-Cell Lymphoma 
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Primary Splenic Lymphoma 
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Angiocentric  Lymphoma - Pulmonary B-Cell
Anaplastic Large Cell Lymphoma
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Anaplastic Large Cell Lymphoma

See Childhood Anaplastic Large Cell Lymphoma
See Anaplastic large cell lymphoma
 
Large-Cell, Immunoblastic
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Large-Cell, Immunoblastic

B-cell stage:  mature, after antigen exposure
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PubMed abstracts:  ReviewTherapyDiagnosis
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About  Lymphoma Info Net
Lymphoblastic lymphoma/
leukemia
B-cell stage: precursor b-cell
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Lymphoblastic lymphoma/leukemia

"Lymphoblastic lymphoma. This lymphoma often occurs in young people. Associated with large mediastinal mass (occurring in chest cavity between the lungs) and carries a high risk for spreading to bone marrow and central nervous system."  healthnyt
 

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PubMed abstracts: ReviewTherapyDiagnosis
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Also see: Childhood Lymphoblastic Lymphoma
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Treatment

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Aggressive Non-Hodgkin's Lymphoma: Improved Prognosis With Combination Chemotherapy, Tables  Medscape (free login req.)
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Treatments of NHL (flowcharts) - MDACC  PDF | PDF-Help
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Treatment Guidelines tsrcc.on.ca  PDF | PDF Help
 
Disclaimer:  The information on Lymphomation.org is not intended to be a substitute for 
professional medical advice or to replace your relationship with a physician.
For all medical concerns,  you should always consult your doctor. 
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