Overview
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Large Cell Lymphomas
Generally these are fast growing cancer of b- or t-cells (lymphocytes) - a type of immune cell. Large Cell Lymphomas (LCL) are one of the most common types of aggressive lymphoma, comprising about 31% of lymphomas. These lymphomas appear in both children and adults.
What is lymphoma? It is a condition where abnormal blood cells accumulate - typically in the in the lymphatic system, including the spleen or bone marrow.
See Lymphoma simplified for more detail.
The clinical and pathological features of non-Hodgkin's lymphomas are diverse. For example, there is large cell lymphoma and also intermediate grade or high grade lymphoma. Increasingly, the diagnosis of large cell lymphoma is more refined - beyond the size of the cells - based instead on the type of lymphocyte that is defective and molecular characteristics.
Diffuse Large B Cell Lymphoma accounts for for about 30% of all non Hodgkin lymphomas. It may first show itself as a extra-nodal mass -- outside the lymphatic system -- or as a rapidly growing nodal mass (enlarging lymph node).
See Diffuse Cell Lymphoma page.
The characteristics of the lymphoma at diagnosis as determined by the pathology report, and it's actual clinical behavior, and other factors determine the type of treatment and the timing of treatment you and your doctor will consider.
Types of large cell lymphomas
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Lymphoma Series: Variants of Large-Cell Lymphoma theoncologist.alphamedpress.org | Full PDF
Introduction to a Special Series of Unique Entities Within the Spectrum of Large-Cell Lymphoma, George P. Canellos, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
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Large-Cell, Immunoblastic (high grade) *
PubMed abstracts: Review | Therapy | Diagnosis
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Large B-cell lymphoma PubMed
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Large-Cell, Follicular * Also see Follicular
PubMed abstracts: Review | Therapy | Diagnosis
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Large-Cell, Ki-1 *
PubMed abstracts: Review | Therapy | Diagnosis
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T Cell Rich Large B Cell Lymphoma (a rare subtype of large B cell lymphoma)
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PubMed articles All related articles | PubMed
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T-Cell/Histiocyte–Rich Large B-Cell Lymphoma: A Distinct Clinicopathologic Entity By R. Achten jco.org
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T-Cell/Histiocyte-Rich Large B-Cell Lymphomas and Classical Diffuse Large B-Cell Lymphomas Have Similar Outcome After Chemotherapy: A Matched-Control Analysis R. Bouabdallah,et al jco.org
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OTHER TYPES
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Intravascular B-cell lymphomas (rare)
Report of two cases with different clinical presentation but rapid central nervous system involvement. Leuk Lymphoma. 2003 Aug;44(8):1353-9. PMID: 12952229 Abstracts
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Primary Mediastinal B-Cell Lymphoma
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Primary Splenic Lymphoma
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Angiocentric Lymphoma - Pulmonary B-Cell
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