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Types of Lymphoma >
Waldenström’s
Macroglobulinemia
Last update:
05/05/2013
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TOPICS
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Clinical
Trials | Research News
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Cell Transplants
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Overview of
Waldenstrom's
Macroglobulinemia
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Waldenstrom's
macroglobulinemia (WM) is also called lymphoplasmacytic lymphoma, or a
lymphoplasmacytic disorder.
WM is a cancer of mature plasma cells, B
lymphocytes, which causes overproduction of an antibody called IgM,
which causes the blood to become too thick (hyperviscosity).
(Science talk - Jargon: the overproduction of the antibody is
called monoclonal
macroglobulin (IgM) antibody OR monoclonal IgM gammopathy).
This blood thickening (hyperviscosity) interferes with blood flow through small blood vessels, which leads to many of the symptoms of the
disease.
WM also presents with bone marrow infiltration and often
with clinical symptoms such as neuropathy
B-cell stage: mature, plasma cells
In the News
Symptoms may
include
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fatigue (from anemia) |
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weight loss |
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headache |
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dizziness, mental status changes |
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bruising of the skin, rash, nosebleeds, bleeding gums |
Sometimes people have no symptoms and
it is found by chance following a blood test.
Diagnosis
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A blood
test The blood tests will show the number of abnormal cells present and the amount of the
IgM antibody in your blood. |
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Bone
marrow biopsy to determine if abnormal cells are present in
marrow. |
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Ultrasound
Lets the doctor see if your liver or spleen is enlarged. |
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CT scan
X-ray images are taken from different angles which are processed
by a computer to create detailed pictures of the inside of the body.
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Resources
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IWMF-Talk -
Internet Discussion Forum
Support specific to Waldenstrom's
macroglobulinemia |
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Bing Center for WM Research
wmprogram.com
"Comprehensive recommendations for the diagnosis and therapy of Waldenstrom's Macroglobulinemia including the consensus panel reports from the 2nd International Workshop on Waldenstrom's Macroglobulinemia held in Athens, Greece."
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www.wmprogram.com/Diagnosis/Default.asp
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Consensus Panel Recommendations from the
Second International
Workshop on Waldenstrom’s Macroglobulinemia
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Consensus Panel Recommendations from the
Second International
Workshop on Waldenstrom’s Macroglobulinemia
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Detailed
- Guidelines
for diagnosis and therapy - BSH
PDF
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Treatments
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Treatments
TOPIC
SEARCH:
SearchMedica
Waldenström's Macroglobulinemia is a slowly
progressing, or chronic, condition. You may not need treatment and
will be monitored with blood tests instead. Some people may
never require treatment.
Apheresis
(also called plasmapheresis or plasma exchange)
medlib.med.utah.edu
"The process of apheresis involves removal of whole blood from a patient or donor. Within an instrument that is essentially designed as a centrifuge, the components of whole blood are separated. One of the separated portions is then withdrawn and the remaining components are retransfused into the patient or donor." PAL
Chemotherapy
may include Leukeran, Alkeran, Cytoxan, Fludarabine, Rituxan, or
steroids.
Splenectomy is the surgical resection
(removal) of an enlarged spleen. Case reports indicate this procedure
can be effective in treating WM
Related
PubMed abstracts | About splenectomy
Waldenström’s Macroglobulinemia:
Questions and Answers Cancer.gov
Includes How is Waldenström’s macroglobulinemia
treated?
ARTICLES
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NEW Novel
Treatment Regimens for Waldenström’s Macroglobulinemia: Other
Drugs under Investigation in Waldenström's Macroglobulinemia
http://bit.ly/cxzcal |
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Bing Center researchers publish
two new papers on mast cells and WM
wmprogram.com
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Mast cells in Waldenstrom's
macroglobulinemia support lymphoplasmacytic cell growth through
CD154/CD40 signaling
wmprogram.com/
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A Phase I/II Study of TACI-Ig To Neutralize APRIL and
BLyS in Patients with Refractory or Relapsed Multiple Myeloma or
Active Previously-Treated Waldenström's Macroglobulinemia.
Session Type: Poster Session 770-II
ASH
2005
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Predictive Factors for Response and Progression after
Treatment with Rituximab in Previously Untreated Patients with
Waldenstrom's Macroglobulinemia (WM). Session Type: Poster Session
736-III
ASH
2005
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Phase II Study of Bortezomib [Velcade] in
Waldenstrom's Macroglobulinemia: Results of WMCTG Trial 03-248.
Session Type: Oral Session
http://clincancerres.aacrjournals.org
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Durable remission after splenectomy for Waldenstrom's
macroglobulinemia with massive splenomegaly in leukemic phase.
Leuk Lymphoma. 1997 Jul;26(3-4):387-93.
PMID: 9322902
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Related
articles
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Use of iodine 131I-tositumomab radioimmunotherapy in a patient
with Waldenstrom's macroglobulinemia.
Leuk Lymphoma. 2004 Mar;45(3):591-5.
PMID:
15160923
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Treatment of Waldenstrom's macroglobulinemia with rituximab.
J Clin Oncol. 2002 May 1;20(9):2327-33. PMID: 11981004
PubMed
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Fludarabine therapy in Waldenstrom's macroglobulinemia
patients treated previously with 2-chlorodeoxyadenosine. Leuk
Lymphoma. 2002 Feb;43(2):361-3.
PMID: 11999570
PubMed
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Treatment of Waldenstrom's macroglobulinemia with rituximab.
J Clin Oncol. 2002 May 1;20(9):2327-33.
PMID:
11981004
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Extended Rituximab
Therapy for Previously Untreated Patients with Waldenstrom's
Macroglobulinemia. Clin Lymphoma. 2002 Dec;3(3):163-6. PMID:
12521393
PubMed
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Clinical Trials
and Research Centers
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Clinical Trials
and Research Centers
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ClinicalTrials.gov
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WM Clinical Trials Group (WMCTG)
Dana Farber Cancer Inst, MA
UCLA Medical Ctr., CA
Stanford University, CA
Beth Israel Hospital, MA
Roswell Park Memorial, NY
St. Vincent's Hospital, NY
LI Jewish Memorial, NY
University of Maryland, MD
University of Miami, FL
Cleveland Clinic Foundation, OH
Northwestern University, IL
Rush Presbyterian, IL
Rocky Mountain Cancer Ctr., CO
Arizona Cancer Ctr., AZ
McMaster University, Canada
Cross Cancer Ctr., Canada
St Bartholomew's, UK
Karolinska Institut, Sweden
Hopital Schaffner, France
University of Salamanca, Spain
Niguarda Hospital, Italy
McCallum Cancer Ctr., Australia |
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Research News
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Research News
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Waldenstrom's macroglobulinemia: a review of therapy.
Leuk Lymphoma. 2002 Aug;43(8):1517-26. PMID: 12400593
PubMed
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