Extranodal NK/T-cell lymphoma, nasal type is
an aggressive lymphoma that is very rare but more common in Asian and
Hispanic communities. It can involve the nasal area, the trachea, the
gastrointestinal tract, or skin.
"Normal Natural Killer cells are a certain type of white blood cell that attacks tumour cells and infected body cells by binding to a tumour cell and releasing lethal chemicals. Natural killer cells are thought to play a key role in cancer prevention by killing abnormal cells before they multiply and grow."
"Because NK-cell lymphomas express some T-cell
markers, they may be mistakenly diagnosed as peripheral T-cell
lymphomas if they are not investigated for the NK-cell-specific
marker, CD56. Therefore the importance of immunophenotypic
investigations of CD56 should be stressed. Also, the importance of
clinical investigation of nasal/nasopharyngeal lymphomas should be
stressed when NK-cell lymphoma is diagnosed involving the skin,
because NK-cell lymphomas are often associated with the nasal and
nasopharyngeal region." 
Resources and News
2017: Targeting NK
Cells for Anticancer Immunotherapy: Clinical and Preclinical
http://bit.ly/2pkoV6Y (full text)
Blood, Eric Tse and Yok-Lam
How I treat NK/T-cell lymphomas
Lima, 2013 review: Aggressive
mature natural killer cell neoplasms: from epidemiology to
T Cell and NK Cell Lymphoproliferative Disorders
John P. Greer, Marsha C. Kinney and Thomas P. Loughran, Jr.
ASH Edu book 2001
Peripheral T-cell lymphoma [NK-type]
Curr Oncol Rep. 2002 Sep;4(5):434-42. Review. PMID: 12162919
Characterization of novel natural killer (NK)-cell and
T-cell lines established from primary lesions of nasal T/NK-cell
lymphomas associated with the Epstein-Barr virus Blood
Efficacy of ifosfamide, methotrexate, etoposide and prednisone
(IMEP) chemotherapy in extranodal NK/T-cell lymphoma, nasal type.
Dose-intensive CHOP chemotherapy followed by radiation for localized NK/T-cell lymphoma.
Nasal and nasal-type T/NK-cell lymphoma with cutaneous
involvement. J Am Acad Dermatol. 1999 May;40(5 Pt 2):850-6. PMID:
10321634 | Related
Nasal-type NK/T cell lymphoma of the orbit with distant
Hum Pathol. 2003 Mar;34(3):290-2. PMID:
12673566 | Related
Article - Subtypes of Lymphoma ASCO.org
Long-term remission of
blastic natural killer-cell lymphoma after autologous peripheral
blood stem-cell transplantation. Am J Hematol. 2005
16184583 | Related
Extranodal natural killer/T-cell lymphoma, nasal type.
Cancer. 2005 Dec 20;
In the management of nasal NK/T-cell lymphoma, the RT field
affected treatment outcomes. RT doses >/= 50 Gy resulted in
favorable local control. PMID:
16369986 | Related
Case report: Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation
A 43-year-old female underwent allogeneic HSCT for
advanced-stage, chemorefractory ENKL, and achieved complete
response. In 4 months after the transplantation, however, the ENKL
relapsed in multiple sites. These lesions markedly responded to
the discontinuation of immunosuppressive agents and disappeared.
Except for a temporal exacerbation of bronchiolitis obliterans
organizing pneumonia, she has been free from disease for more than
a year without other treatments against lymphoma. The clinical
course of the current patient suggests the potent GVL effect
showed favorable outcome in treating early stage extranodal
nasal-type NK/T-cell lymphoma in children and adolescents.
Radiation and Weekly Cisplatin Followed by VIPD in Newly
Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma, J
Clin Oncol. 2009. (n=32, newly diagnosed pt) PubMed
High Dose Chemotherapy (HDC) and Hematopoietic Stem Cell
Transplant (HSCT) in Peripheral T Cell (PTCL), NK Cell and
Ki-1 Anaplastic Large Cell Lymphoma (ALCL).