About Lymphoma | Advocacy | Art | CAM | Clinical trials | Doctors - Experts - Centers | Guidelines at Diagnosis | News
Risk Factors | Side Effects | Statistics | Support | Symptoms | Tests | Treatments | Types of Lymphoma

Search Site         Guidelines at Diagnosis | About Clinical Trials            How to Help!

Patients Against Lymphoma

 

Treatments > Chemo agents, Alphabetical Index

Last update: 04/30/2014

A | B | C | D | E | F | G | H | I | J | K | L | M | N
 O | P | Q | R | S | T | U | V | W | X | Y | Z
Also see Drug Indexes: 
NCI Drug Index  | | Daily Meds database

Chemocare resources:

Chemotherapy drug index side effect information
Common Chemotherapy Acronyms, Regimens, and Abbreviations
 

A

bullet
Adriamycin®, (Doxorubicin, Rubex®) Druginfo
bullet
Ara-C (Cytarabine, Cytosine Arabinoside, Cytosar) Cancer.gov
Return to top

B

bullet
Bendamustine (Treanda (r) ) Dailymed   > Treatment abstracts  | Cancer.gov | Scholar Search
bullet
Full prescribing information http://www.treanda.com/pdf/TREANDA_final_PI.pdf
bullet
Patient information: http://www.mayoclinic.com/health/drug-information/DR602629
bullet
B-R vs. CHOP-R, Cheson - Medscape: Lymphoma: More a Question of Toxicity Than Efficacy
bullet
Medscape: Is R-Benda a New Standard in Lymphoma? http://bit.ly/X5Azh5 
video discussion by Dr Cheson
bullet
Pivotal Study:

Bendamustine Plus Rituximab Is Superior to CHOP Plus Rituximab as First-Line Treatment of Patients with Advanced Follicular, Indolent, and Mantle Cell Lymphomas: Final Results of a Randomized Phase III Study of the StiL (Study Group Indolent Lymphomas, Germany) http://bit.ly/5CC1nt 
bullet
Bendamustine: Safety and Efficacy in the Management of Indolent NHL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117628/
bullet
Treanda (Bendamustine) Full Prescribing information FDA  PDF  
bullet
Side effects reported: ehealthme.com
bullet
Onclive: What is best way to administer bendamustine (vesicant/irritant)? http://bit.ly/Vmm8zc 
bullet
Clinical Experience With Bendamustine: New Treatment for Patients With CLL: Dose and Administration Guidelines http://www.medscape.com/viewarticle/584893_6
bullet
Bendamustine in Patients With Rituximab-Refractory Indolent and Transformed Non-Hodgkin's Lymphoma: Results From a Phase II Multicenter, Single-Agent Study http://jco.ascopubs.org/cgi/content/full/26/2/204  
bullet
Bendamustine (Treanda) For Chronic Lymphocytic Leukemia
A Brief Overview pubmedcentral.nih.gov
bullet
Bendamustine, but not Fludarabine, - low stem cell toxicity in vitro. http://bit.ly/aOgmrR
bullet
Bendamustine HCL for the treatment of relapsed indolent NHL  http://bit.ly/cDZmsl (full text)
bullet
Bendamustine for CNS involvement?  http://jco.ascopubs.org/cgi/content/abstract/22/17/3608
bullet
Bleomycin (Blenoxane®)  SearchMedica
bullet
brentuximab vedotin (Adcetris)
bullet
Topic Search ncbi.nlm.nih.gov
bullet
FDA Briefing Document
Oncologic Drugs Advisory Committee Meeting
July 14, 2011 | BLA 125388
(Adcetris) brentuximab vedotin

Proposed Indication: Treatment of Relapsed or Refractory Hodgkin Lymphoma
bullet
Bexxar PAL | SearchMedica | Scholar Search
Return to top

C

bullet
Carboplatin (Paraplatin®)  Cancer.gov
bullet
Carmustine (BCNU®)  Cancer.gov  
bullet
Chlorambucil (Leukeran®)    Druginfo.gov | DailyMeds.gov

Also see Treatment abstracts
bullet
Chlorodeoxyadenosine (Cladribine®)  MedlinePlus 
Other names:  2-chlorodeoxyadenosine; 2-CdA
Cisplatin (Platinol®) Cancer.gov
bullet
Cyclophosphamide injection (Cytoxan®) Cancer.gov
bullet
Potential Immune-modulating effects of Cytoxan: PubMed query
bullet
Cytarabine  (cytosine arabinoside, Ara-C, Cytosar)  Cancer.gov
Return to top

D

bullet
Dacarbazine (DTIC®) BCCancer  
bullet
Deltasone® (Prednisone tablets) full prescribing information
www.pfizer.com/download/uspi_deltasone.pdf
 
bullet
Dexamethasone (Decadron®) BCCancer  
bullet
Doxorubicin (Adriamycin®, Rubex®)  DrugInfo.gov
bullet
Doxorubicin, Liposomal (Doxil) Medline | cancer.gov  
Full prescribing info from Doxil.com  PDF
Return to top

E

bullet
Etoposide IV (VP-16, VePesid®, Etopophos) Cancer.gov | Cancerbacup   
Return to top

F

bullet
Fludarabine IV (Fludara®)   Full Prescribing Details 
bullet
What is FCR? http://bit.ly/PBQkI6 

Dr. Sharman's CLL & Lymphoma Blog
An excellent explanation. A good read- even if your battle is not with CLL.
bullet
Fludarabine oral  (Fludara®)  Cancer.gov 
Return to top

G

bullet
Gemcitabine (Gemzar®) Cancer.gov
bullet
PubMed search: 

Gemcitabine And Lymphoma ncbi.nlm.nih.gov | Treatment abstracts
Return to top

H

Return to top

I

bullet
Idarubicin (Idamycin®)   
bullet
Ifosfamide (ifex®)Lomustine (CCNU®)   DrugInfo.gov
Return to top

J

Return to top

K

Return to top

L

bullet
Leukeran® (Chlorambucil) Cancer.gov | Treatment abstracts
bullet
Liposomal Doxorubicin (Doxil) chemocare.com  
Full prescribing info from Doxil.com PDF | PDF-Help 
bullet
Liposomal vincristine (investigational) (Onco TSC) in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol. 2000 Jan;11(1):69-72. PMID: 10690390  PubMed | Abstracts

 

Return to top

M

bullet
Mechlorethamine (nitrogen mustard, Mustargen®) BCCancer
bullet
Melphalan (Alkeran®) BCCancer 
bullet
Mercaptopurine oral (Purinethol®) BCCancer
bullet
Methotrexate oral (Rheumatrex®) BCCancer

Other name: amethopterin
bullet
Methotrexate infusion  BCCancer

Why does he need to have his system flushed after receiving the Methotrexate?

Andy wrote: Chemo is great for us when it is in the cancer cells. Pretty much everywhere else in the body, however, it is toxic. So, once it goes through the blood stream and starts moving into the kidneys and bladder, then you want to keep it moving along.

That's why you are supposed to stay well hydrated with chemo. While I haven't had methotrexate, I imagine that something very similar is the issue. I looked over the methotrexate prescribing info and it looks like there can be a lot of variability in how long it takes to clear out of the system and there are things they can help to flush it out and prevent damage to organs. How much of the 4 days is the infusion and then how much is the flushing time?
bullet
Methylprednisolone (Medrol®) Medline
bullet
Mitoxantrone full prescribing information:
www.osip.com/OSI/images/docs/NovantronePI1-2003.pdf  | BCCancer 
bullet
Mitoxantrone (Novantrone®) BCCancer 
Return to top

N

Return to top

O

bullet
ONTAK (denileukin diftitox) chemocare.com
bullet
2012 - Ofatumumab  - Chemoimmunotherapy with Ofatumumab in combination with CHOP in previously untreated follicular lymphoma onlinelibrary.wiley.com/

 

Return to top
 

P

Return to top

Q

Return to top

R

Return to top

S

Return to top

T

  • Thalidomide Topic Search | Cancer.gov
  • Thioguanine oral (Lanvis®) 
  • Trofosfamide (palliative/elderly) as a salvage treatment with low toxicity in malignant lymphoma.

    A phase II study. Eur J Cancer. 1997 Mar;33(3):500-2. PMID: 9155539  PubMed  | Abstracts
Return to top

U

Return to top

V

  • Vinblastine (Velban®) 
  • Vincristine (Oncovin®)  Cancer.gov | Full Prescribing Document

    NOTE: Adjusting the dose of Vincristine is common due to variable way individuals metabolize the drug and differences in half-life.  
     
    Clearance of the drug can vary from 23 to 85 hrs for adults; 
    and from 10 to 40 hrs in children. Source bccancer.bc.ca 

    Notify your doctor of symptoms associated with this drug. 

    "The neurotoxicity commonly manifests as ... constipation, and peripheral neuropathy which is predominantly sensory in nature. The early symptoms include numbness and tingling of hands and feet which is accompanied by loss of deep tendon reflexes. In its more severe form, muscle weakness develops which is more marked in distal muscles of the hands and feet. Other manifestations of neurotoxicity include ocular palsies, hoarseness of voice, and autonomic neuropathy in the form of postural hypotension and atony of the urinary bladder. The neurotoxicity is dose related and cumulative with repeated dosage such that the drug therapy has to be stopped after a cumulative dose of 30 to 50 mg. The neurotoxicity is usually reversible on interruption of the therapy, but the recovery is slow and takes several months. There are no specific antidotes which have established usefulness against neurotoxicity." PMID

    Predicting toxicity? "Raised level of serum alkaline phosphatase may predict severe neurotoxicity" 1

    1 Can severe vincristine neurotoxicity be prevented? 
    Cancer Chemother Pharmacol.
    1982;8(2):211-4.
    PMID: 6125275 | Related Articles

    Side effects of Vincristine, and when to inform your doctor: 
     
    Contact your doctor immediately, if
       Fever over 100 degrees - indicating possible infection
     
    Contact your doctor as soon as possible, if
       Lower back or side pain - indicating possible kidney problems
       Swelling of feet or lower legs
       Gout-like joint pain
       Changes in eye sight, blurry vision, or drooping eyelid
       Trouble walking or climbing stairs
       Severe constipation or stomach cramps
       Difficulty urinating, or frequent need to urinate - bed-wetting
     
    Contact your doctor when needed, if these symptoms continue to bother you
       Uncontrolled nausea, vomiting, constipation or diarrhea
       Easy bruising or bleeding
       Severe jaw pain or headache
       Redness, swelling, pain or sores where the needle was placed
       Redness, swelling, pain or sores on your lips, tongue, mouth or throat
     
    adapted from BCCancer
  • Vincristine, liposomal (investigational) (Onco TSC) in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol. 2000 Jan;11(1):69-72. PMID: 10690390  PubMed | Abstracts
  • Velcade approved for Multiple Myeloma will be available off label to patients with NHL  Abstracts
    • Background: Managing and avoiding bortezomib (Velcade) toxicity 
      Jeffrey Menashe, MD | Northwest Cancer Specialists, Portland, OR
       communityoncology.net pdf 
    • Dietary flavonoids inhibit the anti-cancer effects of the proteasome inhibitor Bortezomib (Velcade)

      Dietary flavonoids, quercetin and myricetin, which are abundant in plasma, inhibited Bortezomib-induced apoptosis of primary CLL and malignant B-cell lines in a dose-dependent manner. 

      Blood First Edition Paper, pre-published online 
      July 16, 2008; DOI 10.1182/blood-2008-04-150227.

      Sources of flavonoids: http://lpi.oregonstate.edu/infocenter/phytochemicals/flavonoids/ 
  • Vinorelbine (Navelbine®)  FDA | Treatment abstracts
    (
    Vinca alkaloid that interferes with microtubule assembly)
Return to top

W

Return to top

X

Return to top

Y

Return to top

Z

Return to top
 
Disclaimer:  The information on Lymphomation.org is not intended to be a substitute for 
professional medical advice or to replace your relationship with a physician.
For all medical concerns,  you should always consult your doctor. 
Patients Against Lymphoma, Copyright © 2004,  All Rights Reserved.