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Types of Lymphoma > Testicular Lymphoma

Last update: 03/12/2014

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 TOPIC SEARCH: ASCO.org | ASH.org | ASHeducation Books | JCO.org | PubMed 

Background on testicular lymphoma

"Testicular lymphoma is a rare extranodal presentation of non-Hodgkin lymphoma."  Extranodal means the location of the malignant cells was found outside lymphoid organs (lymph nodes). 

"Prognosis depends on the type and stage of lymphoma. The usual treatment is surgical removal, followed by radiation and/or chemotherapy." 

What Is Testicular Cancer?  cancer.org   

"Involvement of “sanctuary” sites, which include the CNS and testicles, is more frequently associated with Burkitt's NHL and non-Burkitt's small-cell NHL, T-ALL, primary testicular diffuse large-cell lymphoma [23], HIV-associated aggressive B-cell lymphoma, and HTLV-1 associated lymphoma."  cancernetwork.com/textbook 

Lymphoma, leukemia, and melanoma are the most common malignancies that metastasize to the testicle."  emedicine  

See WHO Classification


Lymphoma is the most common secondary testicular cancer. Among men older than 50, testicular lymphoma is more common than primary testicular tumors. 

"Testicular cancer, which is rare in the United States (about 1% of all cancers in males), is more common worldwide among whites than blacks or Hispanics."  

Assessment of the Scientific Information for the Radiation Exposure Screening and Education Program (2005)  cache.search.yahoo

Also see: ncbi.nlm.nih.gov


To make an accurate diagnosis of lymphoma, a biopsy must be performed by the surgical removal (resection) of a lymph node.  A fine needle aspiration may be performed if a lymph node is not accessible, but this is not considered a definitive way to determine the diagnosis.

A series of tests will then be performed to determine the characteristics of the cells.  If a malignancy is determine, these characteristics will allow your doctors to determine the appropriate treatments to use when needed. 


Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer. 2000 Jan 1;88(1):154-61. PMID: 10618618 | Related articles
Testicular, Malignant Tumors  emedicine
What is testicular cancer  cancer.org 


   Outcome ASCO | Medscape | PubMed

NEW Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature

Stage I-IIE primary non-Hodgkin's lymphoma of the testis: results of a prospective trial by the GOELAMS Study Group.
Clin Lymphoma. 2002 Dec;3(3):167-72. PMID: 12521394 

After a median follow-up period of 73.5 months, the probability of disease-free survival (DFS) and overall survival (OS) were 70% and 65%, respectively for all patients. Disease-free survival and OS were 66% and 83% in patients = 60 years of age, and 74% and 56% in patients > 60 years of age. Relapse occurred in extranodal sites in 4 cases and in abdominal lymph nodes in the last case. Relapse in the CNS occurred in only 1 patient and in the contralateral testis in 1 patient. We found no correlation between OS, DFS and extent of testicular involvement..
Testicular lymphoma: organ-specific treatment did not improve outcome.
Oncology. 2004;67(3-4):211-4. PMID: 15557780
Diffuse large-cell lymphoma of the testis. 
J Clin Oncol. 1999 Sep;17(9):2854-8. PMID: 10561362
Localized non-Hodgkin lymphoma of the testis: the Sheffield Lymphoma Group experience. Int J Oncol. 2005 Apr;26(4):1093-9. PMID: 15754007 

the evidence points to a combined modality approach being the most likely effective treatment, comprising surgery, anthracycline-containing combination chemotherapy with or without prophylactic contralateral testis and regional lymph node irradiation."

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