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Chemo-Protective & Enhancing > Fish oil & Lymphoma abstracts

Last Update: 09/12/2011

The abstracts within do not demonstrate proof of benefit or absence of risk.  
See Evaluating Medical Claims & Data for details. 

Chemo-protective? | Stabilizing? | Treatment Enhancing?

In the News

bullet Univ Med Ctr Utrecht: Mouse study - Fish oil reduces effectiveness of chemotherapy

 

Chemo-Protective Effects?

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Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes. Life Sci. 2002 Sep 6;71(16):1905-16. PMID: 12175705 - PubMed
 
"In conclusion, our results suggest that DHA is able to prevent acute modifications of calcium homeostasis induced by DXR probably interfering with SR Ca(2+) release channels."

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Stabilizing Effects?

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Antiproliferative effect of polyunsaturated fatty acids and interleukin-2 on normal and abnormal human lymphocytes. - Experientia. 1994 May 15;50(5):489-92. - PubMed
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Fatty acids and lymphocyte functions. Br J Nutr. 2002 Jan;87 Suppl 1:S31-48. Review. 
PMID: 11895154 - PubMed 
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Stabilizing effects? Depression of humoral responses and phagocytic functions in vivo and in vitro by fish oil and eicosapentanoic acid. -  Clin Immunol Immunopathol. 1989 Aug;52(2):257-70 - PubMed
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Treatment-enhancing effects of fatty acids in fish oil?

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A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.
Med Hypotheses. 2003 May;60(5):615-23. PMID: 12710892 - PubMed
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Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites?
Prostaglandins Leukot Essent Fatty Acids. 1998 Jan;58(1):39-54. PMID: 9482165 - PubMed 
 
Conclusion: "These results coupled with the observation that various fatty acids can alter the activity of cell membrane bound enzymes such as sodium-potassium-ATPase and 5'-nucleotidase, levels of various anti-oxidants, p53 expression and the concentrations of protein kinase C suggest that essential fatty acids and their metabolites can reverse tumour cell drug-resistance at least in vitro."
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Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. Cancer. 2000 Apr 15;88(8):1916-28. 
PMID: 10760770 - Animal study - PubMed
 
Conclusion: "Fatty acids of the n-3 series normalize elevated blood lactic acid in a dose-dependent manner, resulting in an increase in disease free interval and survival time for dogs with lymphoma. Copyright 2000 American Cancer Society."
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Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. Anticancer Res. 2001 Jan-Feb;21(1A):29-38. PMID: 11299749 - in vitro - PubMed
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Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. Br J Cancer. 1993 Apr;67(4):728-33. PMID: 8385976 - PubMed 
 

Conclusion: "When the interactions between the polyunsaturated fatty acids and cytotoxic drugs were analysed by the isobologram method the toxicities were shown to be additive. The combination of polyunsaturated fatty acids and cytotoxic drugs may have clinical potential provided that the normal tissue toxicities of the two treatments are not additive."
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Effects of polyunsaturated fatty acids on the efficacy of antineoplastic agents toward L5178Y lymphoma cells. - Biochem Pharmacol. 1993 May 5;45(9):1881-7. - PubMed
 
Conclusion: "The data showed that modification of cultured L5178Y cells with highly unsaturated fatty acids, particularly DHA, enhances the toxic action of chemotherapeutic agents."
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Effect of cellular fatty acid alteration on adriamycin sensitivity in cultured L1210 murine leukemia cells. Cancer Res. 1984 May;44(5):1863-6. PMID: 6231987 - in vitro - PubMed 
 
Conclusion: "These data demonstrate that modification of cellular fatty acid composition may dramatically affect the sensitivity of a tumor cell to Adriamycin."
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Effects of polyunsaturated fatty acids on the efficacy of antineoplastic agents toward L5178Y lymphoma cells - Biochem Pharmacol. 1993 May 5;45(9):1881-7. - PubMed 
 
Conclusion: "The data showed that modification of cultured L5178Y cells with highly unsaturated fatty acids, particularly DHA, enhances the toxic action of chemotherapeutic agents."
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