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Treatment Overview or Chemotherapy > Common combinations
Last update: 04/30/2014
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Chemocare resources:
Chemotherapy drug index with side effect information
Common Chemotherapy Acronyms, Regimens, and Abbreviations
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APO
Abstracts
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A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
P = Prednisolone
O = Vincristine (Oncovin®) Blocks Cell Duplication
and Methotrexate (substituted for Doxorubincin when toxicity threshold is reached.)
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ATT
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Alternating Triple Therapy. The protocol involves a sequence of three regimens, CHOD-Bleo, ESHAP, and NOPP. The drugs in these regimens include:
cyclophosphamide, doxorubicin, vincristine, belomycin, VP-16, cisplatin, mitoxantrone, procarbazine, and corticosteriods (prednisone, methylprednione, dexamethasone.) The only overlap with FND is the mitoxantrone and dexamethasone.
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BEAM Mini
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B = Carmustine (BCNU®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
M = Melphalan (Alkeran®) DNA-Altering
Details on BEAM: spitfire.emmes.com
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Bendamustine Treanda
Bendamustine
(SDX-105)
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B = Bendamustine (bifunctional agent with both alkylator and purine-like activity)
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
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BEAC
BEAC or BEAM?
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B = Carmustine (BCNU®) DNA-Altering
E = Etoposide (VP-16, VePesid ®) DNA Repair Enzyme Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
While BEAC and BEAM appears to have equal antitumour efficacy in patients with NHL, BEAM seems to be more toxic to the gastrointestinal tract. However, randomized studies are needed for more definitive conclusions on the relative merits of various high-dose regimens in patients with NHL. PMID: 12916867
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CHOP
CHOP + R
For aggressive or
indolent lymphoma
Abstracts
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Dr. Sharman's CLL & Lymphoma Blog What is R-CHOP?
C = Cyclophosphamide (Cytoxan®) DNA-Altering
H = Doxorubicin (Adriamycin®) or Rubex® or Hydroxydaunomycin Antitumor Antibiotic
O = Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
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CEOP-R
CHOP-like chemotherapy
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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
E = Epirubicin Epirubicin, anthracycline drug nlm.nih.gov
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
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CODOX-M
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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
D = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Methotrexate (Rheumatrex®) Antitumor Antibiotic
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COPBLAM
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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Procarbazine (Matulane®) DNA-Altering
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CP
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C = Chlorambucil (Leukeran®) DNA-Altering
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant |
CVP
CVP + R
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C = Cyclophosphamide (Cytoxan®) DNA-Altering
V = Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
R = Rituxan - Monoclonal antibody against CD20 (addition of Rituxan has become standard)
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CyMiR
Abstracts
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C = Cyclophosphamide (Cytoxan®) DNA-Altering
Mitoxantrone Mitoxantrone (Novantrone®) Antitumor Antibiotic
Rituxan
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DHAP
Abstracts
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D = Dexamethasone (Decadron®) steroidal: anti-inflammatory, Immunosuppressant
HA = Cytarabine (Ara-C, Cytosar®) Antimetabolites
P = Cisplatin (Platinol®) DNA-Altering
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
Oxaliplatin Appears Effective (as cisplatin in DHAP & safer) in Treatment Regimen for Recurrent NHL CancerConsultants.com
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DICE
Abstract ncbi.nlm.nih.gov
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D = Dexamethasone (Decadron®) steroidal: anti-inflammatory, Immunosuppressant
I = ifosfamide (ifek®) DNA-Altering
C = Cisplatin (Platinol®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
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EPOCH-R
Abstracts
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E = Etoposide (VP- 16, VePesid®) DNA Repair Enzyme Inhibitor
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
O = Vincristine (Oncovin®) Blocks Cell Duplication
C = Cyclophosphamide (Cytoxan®) DNA-Altering
H = Doxorubicin (Adriamycin®) Antitumor Antibiotic
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
* Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy http://bloodjournal.hematologylibrary.org/content/99/8/2685.long
EPOCH starting dose and treatment days
http://bloodjournal.hematologylibrary.org/content/99/8/2685/T1.expansion.html
How dose is adjusted
http://bloodjournal.hematologylibrary.org/content/99/8/2685/T2.expansion.html
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ESHAP
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E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
S = Methylprednisolone (Medrol®) steroidal: anti-inflammatory, Immunosuppressant
HA = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
P = Cisplatin(Platinol®) ) DNA-Altering
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
Alert: Severe hypomagnesaemia (low magnesium) with tetany following ESHAP protocol - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=64621
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Fludarabine
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Fludarabine (Fludara ®) Antimetabolites
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Fludarabine + Rituxan
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F = Fludarabine (Fludara ®) Antimetabolites
R = Rituxan - Monoclonal antibody against CD20
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FCR
Related PubMed articles: Follicular outcomes
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F= Fludarabine (Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
R = Rituxan- Monoclonal antibody against CD20
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FND
FND + R
or R-FND
Abstracts
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F= Fludarabine (Fludara ®) Antimetabolites
D= Dexamethasone steroidal: anti-inflammatory, Immunosuppressant
R = Rituxan- Monoclonal antibody against CD20
Also see:
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Historical perspective on the treatment challenges for low-grade NHL
http://www.clinicaloptions.com/Oncology/Resources/CME%20Options/NHL.aspx (Requires registration to listen/see presentation)
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Improvement of Overall and Failure-Free Survival in Stage IV Follicular Lymphoma: 25 Years of Treatment Experience at The University of Texas M.D. Anderson Cancer Center
http://jco.ascopubs.org/cgi/content/abstract/24/10/1582
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Phase III trial of rituximab/FND in patients with Stage IV indolent lymphoma
http://www.nhlupdate.com/edition/2005/1/cabanillas.htm
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FCM+R
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F= Fludarabine (Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
M = Mitoxantrone ( mye-toe-ZAN-trone) DNA intercalation; DNA topoisomerase II inhibition
R = Rituxan- Monoclonal antibody against CD20
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GDP
Abstracts
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Gemcitabine, dexamethasone and cisplatin is an active and
non-toxic chemotherapy regimen in relapsed or refractory
Hodgkin’s disease: a phase II study by the National Cancer
Institute of Canada Clinical Trials Group
http://annonc.oxfordjournals.org/content/14/12/1762.full.pdf+html
[Efficacy of GDP regimen (gemcitabine, dexamethasone, and cisplatin) on relapsed or refractory aggressive non-Hodgkin's Lymphoma: a report of 24 cases].
http://www.ncbi.nlm.nih.gov/pubmed/19000458
INTERMEDIATE DOSE GEMCITABINE - CISPLATIN COMBINATION CHEMOTHERAPY (GEMCIS) WITHOUT TREATMENT DELAY FOR CYTOPENIA - A NEW STANDARD IN PRE-AUTOGRAFT REMISSION INDUCTION FOR RELAPSED OR REFRACTORY HODGKIN'S DISEASE?
http://online.haematologica.org/eha13/browserecord.php?-action=browse&-recid=2173
Gemcitabine, Dexamethasone, and Cisplatin (GDP) Is An Effective and Well-Tolerated out-Patient Salvage Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) and Hodgkin Lymphoma (HL)
http://ash.confex.com/ash/2010/webprogram/Paper32244.html
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HDMTX
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High dose Methotrexate (Rheumatrex®) Antimetabolites Details ptmd.com
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hyperCVAD
or
R-hyperCVAD
now with Rituxan
for MCL
Related abstracts
Hyper CVAD Followed by SCT for MCL - PubMed
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C = twice daily Cyclophosphamide (Cytoxan®) DNA-Altering
V = Vincristine (Oncovin®) Blocks Cell Duplication
A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
D = Dexamethasone steroidal: anti-inflammatory, Immunosuppressant
R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
The above is alternated with high dose Methotrexate, and Ara-C .
Ara-C®, Cytosar®) Antimetabolites
Methotrexate (Rheumatrex®) Antimetabolites
"The hyperCVAD regimen actually involves two regimens. The hyperCVAD combination is alternated with high doses of methotrexate and cytarabine for four courses. Then high-dose cyclophosphamide and total-body irradiation are followed by autologous stem cell transplantation." - MDACC
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About the hyperCVAD protocol- cancercare.on.ca PDF
Treatment schedule, side effects, monitoring ...
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Mantle cell lymphoma (MCL): Induction therapy with HyperCVAD/High-dose methotrexate and cytarabine (M-C) (±rituximab) improves results of autologous stem cell transplant in first remission. - ASCO 2006
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ICE
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 TOPIC SEARCH on outcomes: ASCO | Medscape | PubMed | Web
on risks: ASCO | Medscape | PubMed | Web
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
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R-ICE
Rituximab and ICE (RICE) as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma bloodjournal
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R = Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
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IMVP-16
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I = Ifosfamide (Ifex®) DNA-Altering
M = Methotrexate (Rheumatrex®) Antitumor Antibiotic
VP = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
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MACOP-B
Related abstracts
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M = Methotrexate (Rheumatrex®) Antimetabolites
A = Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin ®) Blocks Cell Duplication
P = Prednisone (Deltasone ®) steroidal: anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane ®) Antitumor Antibiotic
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MOPP/ABV
Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: report of an intergroup trial. J Clin Oncol. 2003 Feb 15;21(4):607-14.
PMID: 12586796 - PubMed
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(MOPP)
M = Mechlorethamine,
V = Vincristine
P = Procarbazine
P = Prednisone
(ABVD)
A = Doxorubicin
B = Bleomycin
V = Vinblastine
D = Dacarbazine
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M-BACOD
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M = Methotrexate (Rheumatrex®) Antimetabolites: interfers with normal growth
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
A = Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
C = Cyclophosphamide (Cytoxan®) DNA-Altering
V = Vincristine (Oncovin®) Blocks Cell Duplication
D = Dexamethasone steroidal: anti-inflammatory, Immunosuppressant
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O-DICE
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SALVAGE: Phase II study of dexamethasone, ifosfamide, cisplatin and etoposide delivered on an outpatient basis (O-DICE), as salvage chemotherapy for patients with relapsed and refractory lymphoma Year: 2002 Abstract No: 1136
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P = Prednisone (Deltasone®)
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
P = Procarbazine (Matulane®)
C= Cyclophosphamide (Cytoxan®) DNA-Altering
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PMitCEBO
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P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
Mit = Mitoxantrone ( mye-toe-ZAN-trone) DNA intercalation; DNA topoisomerase II inhibition
C = Cyclophosphamide (Cytoxan®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
O = Vincristine (Oncovin®) Blocks Cell Duplication
A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma. Br J Cancer. 2006 Mar 27;94(6):806-13. PMID: 16508640
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Pro-MACE
- CytaBOM
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Prednisone (Deltasone®)
Methotrexate (Rheumatrex®) Antimetabolites: interferes with normal growth
Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
Cyclophosphamide (Cytoxan®) DNA-Altering
Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
Cytarabine (Ara-C', Cytosar®) Antimetabolites: interfers with normal growth
Bleomycin (Blenoxane®) Antitumor Antibiotic
Vincristine (Oncovin®) Blocks Cell Duplication
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R-PACEBOM
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PACEBOM "comprising oral prednisolone together with intravenous doxorubicin, cyclophosphamide and etoposide alternating weekly with intravenous bleomycin, vincristine and methotrexate." R-PACEBOM includes also Rituxan
See for PubMed abstracts: http://www.ncbi.nlm.nih.gov/pubmed?term=PACEBOM
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RICE
Rituximab and ICE (RICE) as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma bloodjournal
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R = Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
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VBM
Efficacy of vinblastine, bleomycin, methotrexate (VBM) chemotherapy with involved field radiotherapy in early stage (I-IIA) Hodgkin disease patients. Leuk Lymphoma. 2003 Nov;44(11):1919-23. Review. PMID: 14738143 | Related articles
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V = Vinblastine (Oncovin®) Blocks Cell Duplication
B = Bleomycin, (Blenoxane®) Antitumor Antibiotic
M = Methotrexate (Rheumatrex®) Antimetabolites: interferes with normal growth
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