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About Lymphoma > Prognostic Indicators > BCL2 Negative?

Last update: 09/16/2012


Here we provide resources on the possible implications of having bcl-2 negative lymphomas.  

Background on BCL2, Apoptosis, and Lymphoma -  
Immunohistochemistry in the Evaluation of Follicular or Nodular Lymphoid Lesions - ~ pdf 
October 2003 by Rodney T. Miller, M.D., Director of Immunohistochemistry 
Diffuse Large B-Cell Lymphoma (DLBCL): 
The t(14;18) is associated with germinal center-derived diffuse large B-cell lymphoma and is a strong predictor of outcome. Clin Cancer Res. 2003 Jun;9(6):2133-9. PMID: 12796378 | Related abstracts
CHOP+ R and bcl2 negative -
Follicular Lymphoma:
Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes. Br J Haematol. 2003 Feb;120(3):424-33. PMID: 12580956  
Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation. J Pathol. 2005 Feb;205(3):329-35. PMID: 15682435
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics. Leukemia. 2002 Nov;16(11):2309-17. PMID: 12399977 | Related articles
Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients. Leukemia. 2003 Jan;17(1):255-9. PMID: 12529690 
Disclaimer:  The information on is not intended to be a substitute for 
professional medical advice or to replace your relationship with a physician.
For all medical concerns, you should always consult your doctor. 
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