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About Lymphoma > Prognostic Indicators > BCL2 Negative?

Last update: 09/16/2012
 

 

Here we provide resources on the possible implications of having bcl-2 negative lymphomas.  

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Background on BCL2, Apoptosis, and Lymphoma - som.soton.ac.uk  
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Immunohistochemistry in the Evaluation of Follicular or Nodular Lymphoid Lesions - ~ propathlab.com pdf 
October 2003 by Rodney T. Miller, M.D., Director of Immunohistochemistry 
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Diffuse Large B-Cell Lymphoma (DLBCL): 
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The t(14;18) is associated with germinal center-derived diffuse large B-cell lymphoma and is a strong predictor of outcome. Clin Cancer Res. 2003 Jun;9(6):2133-9. PMID: 12796378 | Related abstracts
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CHOP+ R and bcl2 negative - hematology.org
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Follicular Lymphoma:
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Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes. Br J Haematol. 2003 Feb;120(3):424-33. PMID: 12580956  
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Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation. J Pathol. 2005 Feb;205(3):329-35. PMID: 15682435
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Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics. Leukemia. 2002 Nov;16(11):2309-17. PMID: 12399977 | Related articles
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Is t(14;18)(q32;q21) a constant finding in follicular lymphoma? An interphase FISH study on 63 patients. Leukemia. 2003 Jan;17(1):255-9. PMID: 12529690 
 
 
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For all medical concerns, you should always consult your doctor. 
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