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Side Effects > Metabolic abnormalities in lymphoma

Last update: 07/10/2012

Introduction | Resources & Research News

Here we list metabolic abnormalities in lymphoma patients undergoing chemotherapy, and links to resources.
The following was adapted from:  Metabolic abnormalities in lymphoma. 
Clin Lymphoma. 2002 Dec;3 Suppl 1:S32-6. PMID: 12521387  PubMed 

Tumor lysis syndrome can result in several metabolic abnormalities, leading to potential renal failure. If these syndromes are identified promptly, they can be corrected.  

Chemotherapy- and lymphoma-associated metabolic abnormalities:


Electrolyte Imbalance, Chemocare.com http://bit.ly/9BTMfm


Hyperuricemia - high uric acid levels
Details: www.emedicine.com/med/topic1112.htm 


Hypercalcemia - high concentrations of calcium compounds are found in the bloodstream.

Detailed and technical : www.emedicine.com/EMERG/topic260.htm 


A Practical Approach to Hypercalcemia www.aafp.org/afp/20030501/1959.html 


Vitamin D caution


Question, could elevated calcium be a sign of relapse or disease?

It seems unlikely if it's the only presenting symptom, based on the following:

"Hypercalcemia is uncommonly associated with lymphoma (particularly the b-cell type) but may be seen in centres where many patients with this disease are treated.

Hypercalcemia readily responds to therapy and is a reversible cause of morbidity, but when associated with lymphoma it usually indicates widespread disease. The mechanism of hypercalcemia is unknown but there is strong evidence for humoral factors that may or may not be related to parathyroid hormone." 

Source: Lymphoma with hypercalcemia ncbi.nlm.nih.gov/


NCI Incidence by Cancer Type cancer.gov/
Lymphomas Incidence (%)
of Hypercalcemia of Malignancy
  Hodgkin lymphoma 0.65.4
  Non-Hodgkin lymphoma, high-grade 1433
  T-cell lymphoma (human T-cell, lymphotrophic virus type 1) 50

 See also - PubMed Topic Search: ncbi.nlm.nih.gov


Hyperphosphatemia - high concentration of phosphates in the circulating blood. 
Details: www.emedicine.com/emerg/topic266.htm 


Hypocalcemia - abnormally low calcium concentration, that can result in muscle cramps, abdominal cramps, spasms, and hyperactive deep tendon reflexes. 
Details: www.emedicine.com/EMERG/topic271.htm 


Hypomagnesemia - abnormally low levels of serum magnesium. "The primary clinical findings are neuromuscular irritability, CNS hyperexcitability, and cardiac arrhythmias."
Details: www.emedicine.com/EMERG/topic274.htm 


Hyponatremia - abnormally low levels of serum sodium concentration.
Details: www.emedicine.com/EMERG/topic275.htm 


Hyperkalemia - a potassium level greater than 5.5 mEq/L. Ranges are as follows: 5.5 - 6.0 mEq/L - Mild condition 6.1 - 7.0 mEq/L - Moderate condition 7.0 mEq/L and greater - Severe condition. Details:  www.emedicine.com/emerg/topic261.htm 

Medicinenet  http://www.medicinenet.com/low_potassium_hypokalemia/article.htm


Related Resources & Research News

Electrolyte imbalance
Metabolic emergencies in the cancer patient. Semin Oncol. 2000 Jun;27(3):322-34. Review.
PMID: 10864220  PubMed
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