NCI Alliance for Nanotechnology in Cancer:
How will nanotechnology be applied to cancer?
"Nano" means small - very small.
Literally, it means one billionth. Nanotechnology is the study and
design of systems at the nanometer scale - the scale of atoms and
molecules. And the technology is being applied now to finding
better ways to treat and detect cancers.
"Nanotechnology is no stranger to oncology: liposomes are early examples of cancer
nanotherapeutics, and nanoscale-targeted magnetic resonance imaging contrast agents illustrate the application of nanotechnology to diagnostics."
Nanoparticles can have multiple actions that can provide
detailed information on many disease processes simultaneously. 1
can deliver multiple therapeutic
agents to a tumor in order to simultaneously attack multiple points
in the pathways involved in cancer.
In vivo nano-biosensors
have the capability of detecting and pinpointing
the location of tumors in the body - as well as metastatic lesions
(tumors that have moved away from the primary site) - that are far
smaller than those detectable using conventional technologies.
Detecting cancer before it spreads completely
changes the game when it comes to treating cancer, since
non-metastatic cancer is rarely fatal. Nano-enabled in vivo sensors
may also provide rapid information on whether a given therapy is
actually working as expected, and targeted nano-based therapeutics
that hone in on tumors stand to increase the efficacy of drugs while
dramatically reducing potential side effects.1
Articles and Webcasts
Nanotechnology in Cancer Spotlighted at NSTI
OPPORTUNITIES AND CHALLENGES
Researchers Explore Possible
Applications of Nanotechnology in Cancer Treatment
Drug delivery: A tiny timely vehicle
"the nanocells containing both drugs resulted in the lowest
toxicity of all of the treatments. This is probably because the
cytotoxic agent is localized to the tumour so effectively"
Method of laser activated nano-thermolysis for elimination
of tumor cells [purging harvested stem cells]. Cancer Lett. 2005
16202512 | Related
cancer center starts testing radio-wave theory
radio-wave in tandem with carbon nanotubes.
Video Journey Into Nanotechnology - nano.cancer.gov
Preclinical: Heat immunotherapy using magnetic nanoparticles
and dendritic cells for T-lymphoma -
"... we investigated the therapeutic effects of
hyperthermia combined with DC immunotherapy on mouse EL4 T-lymphoma."
Nanotherapeutics: Multifunctional Nanoparticles for Drug
Delivery and Targeting -
The use of nanoparticles for drug delivery and targeting is one of
the most advanced, exciting, and clinically important applications
UC Davis Researchers Use Heated
Nanoprobes To Destroy Cancer Cells In Mice -
The experimental system uses bioprobes created
by wedding magnetized iron-oxide nanospheres to radiolabeled
monoclonal antibodies. The bioprobes are cloaked in polymers and
sugars that render them nearly invisible to the body's immune
Scientists Directly Target Cancer Cells Patients Could Avoid Chemotherapy's Effects
SYDNEY (May 10) - An Australian
biotechnology firm said on Thursday it had developed a means of
delivering anti-cancer drugs directly to cancer cells, which aims to
avoid the debilitating toxicity associated with chemotherapy.
"Via antibodies on their surface, these nano-cells target and
latch on to cancer cells. Once attached, the nano-cell is engulfed
and the drug is released directly inside the cancer
preclinical/hopeful: Radio Waves
Fire Up Nanotubes Embedded In Tumors, Destroying Liver Cancer
ScienceDaily (Nov. 1, 2007)
— Cancer cells treated with carbon nanotubes can be
destroyed by non-invasive radio waves that heat up the nanotubes
while sparing untreated tissue, a research team led by scientists
at The University of Texas M. D. Anderson Cancer Center and Rice
University has shown in preclinical experiments.
Non-invasive Targeted Radiofrequency Cancer Treatment
Destroying Cancer Cells with Radio Waves
"The treatment concept: ... a “targeting molecule”
(antibody) is designed that will seek out and attach to or
penetrate through that unique site, the targeting molecule is
chemically attached to a gold nanoparticle or carbon nanotube, and
the combination is injected into the bloodstream of the patient.
The targeting molecule(s) eventually delivers the nanoparticle(s)
to the cancer cell(s). It is particularly exciting that metastatic
cancer cells might also be targeted. Exposure of the area to the
radiowaves causes the nanoparticles to warm sufficiently to kill
the cancer cells. This will require an extensive research effort,
especially to be able to ultimately treat the variety of cancers
potentially susceptible to this treatment approach."
Nano-Basics for Clinicians
A Tutorial September 8, 2008 Milan Mrksich The University of Chicago, HHMI
Preclinical: Thermal ablation of lymphoma cells with